Studies on myoinositol. VI. Effect of myoinositol on plasma lipoprotein metabolism of rats suffering from fatty liver.

To approach the mechanism of the lipotropic effect of myoinositol, rates of incorporations of injected 14C-acetate and 14C-leucine into cholesterol and protein moiety respectively, of plasma lipoprotein of rats, partly recovered from Handler's fatty liver with this cyclitol, were investigated in comparison with those of fatty liver control. The results indicated that the incorporations of these isotopes are equally elevated by curing partly the fatty liver with myoinositol. In addition, higher incorporation of 14C-leucine into microsomal trichloroacetic acid-insoluble fraction was observed with rats injected with myoinositol. It was suggested from these results that myoinositol plays some role in the over-all mechanism of the synthesis and secretion of plasma lipo protein in the liver.